rotigotine HCl

Name	(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride
Synonyms	(6S)- rotigotine HCl Rotigotine hydrochloride CEXBONHIOKGWNU-NUDVEOEASA-N [2H3]-RAC ROTIGOTINE HYDROCHLORIDE SALT 8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]aMino]- (6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride (S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol hydrochloride (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenolhydrochloride (6S)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride (S)-6-(propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride
CAS	125572-93-2
EINECS	603-080-0
InChI	InChI=1/C19H25NOS.ClH/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21;/h3-7,13,16,21H,2,8-12,14H2,1H3;1H/t16-;/m0./s1

Molecular Formula	C19H26ClNOS
Molar Mass	351.93
Density	1.2g/cm3 at 20℃
Melting Point	114-117°C
Boling Point	470.1°C at 760 mmHg
Flash Point	238.1°C
Solubility	Acetone (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly)
Vapor Presure	0-0Pa at 20-25℃
Appearance	solid
Color	white to off-white
Storage Condition	room temp
In vitro study	Rotigotine (N-0923) has a 10-fold selectivity for D3 (pK i 9.2) receptors compared with D2, D4 and D5 (pK i 8.5-8.0) and a 100-fold selectivity compared with D1 receptors (pK i 7.2). In functional studies, Rotigotine (N-0923) behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC 50 respectively: 9.0, 9.4-8.6, 9.7). Rotigotine (N-0923) (10 µM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 µM) slightly protects dopaminergic neurons against MPP + toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone.
In vivo study	In primed rats, Rotigotine (N-0923) (0.035, 0.1 and 0.35 mg/kg) induces contralateral turning behavior in a dose dependent manner. In drug naive rats, the turning behavior induced by Rotigotine, either alone or in combination with SCH 39166, is reduced compared to primed rats.

WGK Germany	2
HS Code	2934990002

Last Update：2024-01-02 23:10:35

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CAS: 125572-93-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

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rotigotine HCl

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